Endocrine Abstracts

Background: Managing hypoparathyroidism in patients with autoimmune polyendocrine syndrome type 1 (APS-1) poses significant therapeutic challenges. The presence of gastrointestinal candidiasis and associated malabsorption complicates treatment and may lead to refractory hypocalcemia. The use of high doses of calcium and active vitamin D metabolites to regulate serum calcium levels frequently results in hypercalciuria, which may cause long-term complications. Consequently, repl...

Background: McCune-Albright Syndrome (MAS) is a rare genetic disorder characterized by polyostotic fibrous dysplasia of the skeleton, "café-au-lait" skin hyperpigmentation, and hyperfunction of endocrine glands. A distinctive feature of the syndrome is the autonomous activation of the ovaries leading to the formation of unilateral, recurring estrogen-producing cysts. Hyperestrogenism in turn causes precocious puberty in girls and anovulation in women with MAS. Thi...